澳门新葡亰手机版

许家林

发布者:姜楠发布时间:2020-09-22浏览次数:12

许家林,博士,澳门新葡亰手机版生化与分子生物学研究所教授,博士研究生导师。2009年于北京协和医学院毕业并获得博士学位。200911月起,在美国罗德岛大学药学院University of Rhode Island)从事博士后研究。20138月进入澳门新葡亰手机版任职。先后主持国家级相关科研项目5项,发表SCI论文约三十篇。


学术兼职

Journal of Biochemical and Molecular Toxicology,British Journal of Nutrition, Clinical Nutrition,BMC Pharmacology and Toxicology, PLoS ONE, andToxicology and Applied Pharmacology等杂志专业审稿人。


科研方向

随着人类饮食结构的改变和现代化程度的加深,肥胖发生呈现不断增高的趋势,并诱发多种其他种类的疾病:糖尿病、心血管疾病、老年病、癌症等,所以阻止肥胖发生至关重要。通过使用多种转基因小鼠动物模型和细胞模型,探索肥胖发生和糖尿病发展的疾病机理;并通过研究多种天然化合物对糖尿病和肥胖等疾病病症的影响,寻求可以有效抑制肥胖和糖尿病等疾病发生和发展的治疗策略。


主持及参与基金项目:

1.国家自然科学基金面上项目:BAP31调节脂肪组织堆积和肥胖发生的作用研究(项目批准号:81974120)55万元,项目主持者。

2.国家自然科学基金面上项目:BAP31在非酒精性脂肪肝和糖代谢中的作用研究(项目批准号:81570788)。58万元,项目主持者。

3.国家自然科学基金主任基金:Nrf2对高脂饮食诱导肥胖引起的免疫紊乱的调节机制的探讨(项目批准号:81341102)。15万元,项目主持者。

4.中央高校基本科研业务费探索导向重点项目:PTP-PEP对肥胖诱导的免疫紊乱的调节机制的探讨。40万元,项目主持者。

5. 中央高校基本科研业务费青年教师科研创新基金项目:BAP31基因敲除诱导SREBP1C激活并促进非酒精性脂肪肝形成。10万元,项目主持者。


代表性论文:

  1. Jialin Xu, Mingxi Li, Yi Zhang, Suo Chu, Yan Huo, Jie Zhao, and Chunpeng Wan. Huangjinya black tea alleviates obesity and insulin resistance via modulating fecal metabolome in high-fat diet-fed mice. Molecular Nutrition Food Research. 2020. (accepted)

  2. Mingxi Li*, Jialin Xu*, Yi Zhang, Suo Chu, Shizhuo Sun, Yan Huo, Jie Zhao, Xiaodi Hu, Chunpeng Wan, Liya Li. Comparative analysis of fecal metabolite profiles in HFD-induced obese mice after oral administration of huangjinya green tea extract. Food and Chemical Toxicology. 2020, 145, 111744.

  3. Yuanyuan Li, Jialin Xu, Dongli Li, Hang Ma, Yu Mu, Xueshi Huang, and Liya Li. Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury via regulating Nrf2 and JNK signaling pathways. Food & Function. 2020, Aug. DOI: org/10.1039/D0FO01338B.

  4. Huifang Li, Nicholas A. DaSilva, Weixi Liu, Jialin Xu, George W. Dombi,Joel A. Dain, Dongli Li, Jean Christopher Chamcheu, Navindra P. Seeram andHang Ma. Thymocid®, a Standardized Black Cumin(Nigella sativa) Seed Extract, Modulates CollagenCross-Linking, Collagenase and Elastase Activities,and Melanogenesis in Murine B16F10 Melanoma Cells. Nutrients. 2020, 12, 2146; DOI: 10.3390/nu12072146.

  5. Liya Li, Hang Ma, Tingting Liu, Zhanjun Ding, Wei Liu, Qiong Gu, Yu Mu, Jun Xu,Navindra P. Seeram, Xueshi Huang, and Jialin Xu. Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice. Journal of Functional Foods. 2020, 70, 103970; DOI: 10.1016/j.jff.2020.103970.

  6. Jialin Xu, Tingting Liu, Yuanyuan Li, Wei Liu, Zhanjun Ding, Hang Ma,Navindra P. Seeram, Yu Mu, Xueshi Huang, and Liya Li. Jamun (Eugenia jambolana Lam.) Fruit Extract PreventsObesity by Modulating the Gut Microbiome inHigh-Fat-Diet-Fed Mice. Molecular Nutrition Food Research. 2019, 63(9):e1801307.

  7. Zhenhua Wu, Fan Yang, Shan Jiang, Xiaoyu Sun and Jialin Xu. Induction of Liver Steatosis in BAP31-Deficient MiceBurdened with Tunicamycin-Induced EndoplasmicReticulum Stress. International Journal of Molecular Sciences. 2018, 19, 2291; DOI: 10.3390/ijms19082291.

  8. Jialin Xu, Tingting Liu, Yuanyuan Li, Chunhui Yuan, Hang Ma, Navindra P. Seeram, Feifei Liu, Yu Mu, Xueshi Huang and Liya Li. Hypoglycemic and hypolipidemic effects oftriterpenoid-enriched Jamun (Eugenia jambolanaLam.) fruit extract in streptozotocin-induced type1 diabetic mice. Food and Function. 2018, 9, 3330.

  9. Jialin Xu, Chunhui Yuan, Guihua Wang,Jiaming Luo, Hang Ma, Li Xu, Yu Mu, Yuanyuan Li, Navindra P. Seeram, Xueshi Huang, and Liya Li. Urolithins Attenuate LPS-Induced Neuroinflammation inBV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways. J Agric Food Chem. 2018, 24; 66(3):571-580.

  10. Jialin Xu, Liya Li,Yanqing Wang,Yaqi Li, Mu Shan, Shizhuo Sun, Yang Yu, Bing Wang.  Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. J Lipid Res.2018, 59(1):35-47.

  11. Kunwei Niu, JialinXu, YuhuaCao, Yue Hou, Mu Shan, YanqingWang, YangXu, Mingyi Sun & BingWang.  BAP31 is involved in T cell activation through TCR signal pathwaysactivation through TCR signalpathways.  Sci.Rep. 2017, 7, 44809; DOI: 10.1038/srep44809.

  12. HangMa, JialinXu, NicholasA.DaSilva, LingWang, ZhengxiWei, LiangranGuo, ShelbyL.Johnson, WeiLu, JunXu, QiongGu, NavindraP.Seeram. Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells. Arch Dermatol Res, 2017, 309:265–274.

  13. Yuanyuan Li*, Jialin Xu*, Chunhui Yuan, Hang Ma, Tingting Liu, Feifei Liu, Navindra P. Seeram,Yu Mu, Xueshi Huang, Liya Li. Chemical composition and anti-hyperglycaemic effects of triterpenoidenriched Eugenia jambolana Lam. berry extract. Journal of Functional Foods 2017, 28:1–10.

  14. Jialin Xu, Prajakta Shimpi, Laura Armstrong, Deanna Salter, Angela L. Slitt.  PFOS induces adipogenesis and glucose uptake in association withactivation of Nrf2 signaling pathway. Toxicology and Applied Pharmacology. 2016, 290:21-30.

  15. Liya Li*, Jialin Xu*, Yu Mu, Li Han, Ruohan Liu, Yaping Cai, Xueshi Huang. Chemical characterization and antihyperglycaemiceffects of polyphenolenriched longan (Dimocarpus longan Lour.)pericarp extracts. Journal of Functional Foods. 2015, 13:314-322.

  16. Jialin Xu,Ajay C Donepudi, Vijay R More, Supriya R Kulkarni, Liya Li, Liangran Guo, Bingfang Yan, ChatterjeeTapan, Weintraub Neal, and Angela L Slitt.  Deficiency in Nrf2 Transcription Factor Decreases Adipose TissueMass and Hepatic Lipid Accumulation in Leptin-Deficient Mice. Obesity.  2014, 23:335-344.

  17. Supriya R. Kulkarni, Ajay C Donepudi, Jialin Xu, Wei Wei, Qiuqiong C. Cheng, Maureen Varina Driscoll, Jeffrey A. Johnson, and Angela L. Slitt.  Fasting Induces Nuclear Factor E2-Related Factor 2and ATP-Binding Cassette Transporters via ProteinKinase A and Sirtuin-1 in Mouse and Human. Antioxidants & Redox Signaling. 2014, 20(1):15-30.

  18. Jialin Xu, Ajay C. Donepudi, Jamie E. Moscovitz, and Angela L. Slitt.  Keap1-knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue. PlOS ONE. 2013, 8(11).

  19. Kulkarni SR, Xu Jialin, Donepudi AC, Wei W, Slitt.Effect of Caloric Restriction andAMPK Activation on Hepatic Nuclear Receptor, Biotransformation Enzyme, and Transporter Expression in Lean and Obese Mice. Pharmaceutical Research. 2013, 30(9):2232-47.

  20. Vijay More, Jialin Xu, Prajakta Shimpi, Clyde Belgrave, James Luyendyk, Masayuki Yamamoto, Angela Slitt.  Keap1 Knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radical Biology and Medicine. 2013, 61:85–94.

  21. Lauren M. Aleksunes,Jialin Xu, Eugenia Lin, Xia Wen, Michael J. Goedken and Angela L. Slitt.  Pregnancy Represses Induction of Efflux Transporters in Livers of type I Diabetic Mice.  PharmaceuticalResearch.  2013, 30(9):2209-20.

  22. Laura E. Armstrong, Maureen V. Driscoll, Ajay C. Donepudi, Jialin Xu, Angela A. Baker, Lauren Aleksunes, Jason R. Richardson, and Angela L. Slitt.  Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression. Journal of Biochemical and Molecular Toxicology. 2013, 27(2):165-71.

  23. Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, and Angela L. Slitt.  Enhanced Nrf2 Activity Worsens Insulin Resistance,Impairs Lipid Accumulation in Adipose Tissue, andIncreases Hepatic Steatosis in Leptin-Deficient Mice. Diabetes. 2012, 61:3208–3218.

  24. Jialin Xu, Supriya Kulkarni, Liya Li and Angela L. Slitt.  UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis. Drug Metabolism and Disposition.  2012, 40 (2):259-66.

  25. Yao Song*, Jialin Xu*, Yanfeng Li, Chunshi Jia, Xiaowei Ma, Lei Zhang, Xiaojie Xie, Yong Zhang, Xiang Gao, Youyi Zhang, Dahai Zhu.  Cardiac ankyrin repeat protein attenuates cardiac hypertrophy by inhibition of ERK1/2 and TGF-β signaling pathways. PlOS ONE. 2012, 7(12): e50436.

  26. Tao Yuan, Yuanqing Ding, Chunpeng Wan, Liya Li, Jialin Xu, Ke Liu, Angela Slitt, Daneel Ferreira, Ikhlas A. Khan, Navindra P. Seeram.  Antidiabetic Ellagitannins fromPomegranate Flowers: Inhibition ofα Glucosidase and Lipogenic GeneExpression.Organic Letters. 2012, 14 (20):5358–5361.

  27. Seeram Navindra, Jialin Xu, Liya Li, Angela Slitt. Pharmacy research at URI: mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes.Med Health RI. 2012, 95(9):283-4.

  28. 许家林,李艳凤,朱大海。心肌锚定重复序列蛋白基因心脏特异敲除小鼠模型构建与鉴定。基础医学与临床, 2011, 31(11):1217-1222

  29. Jianwei Ye, Yong Zhang, Jialin Xu, Qiang Zhang, Dahai Zhu.  FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Gene.2007, 404: 53–60.


联系方式

地址:辽宁省沈阳市浑南区创新路195号,澳门新葡亰手机版,生化与分子生物学研究所

办公电话:024-83656117

邮编:110819    E-mailJialin_xu@mail.neu.edu.cn